This was the Virtual NeuroGASTRO 2021 The main 2021 Neurogastroenterology event was the “5th Meeting of the European Society of Neurogastroenterology and Motility - NeuroGASTRO 2021”. It was the first (and hopefully the single) European Neurogastroenterology meeting to be held only virtually due to the Covid pandemic. A marathon of Neurogastroenterology was held between September 2nd to 4th, (sometimes until late in the night), with key opinion leaders presenting State-of-the-Art topics in the field and young scientists showing their papers. The outstanding programme included a wide array of topics such as diagnosis, evaluation and management of digestive motility diseases and future diagnostic and therapeutic approaches. The programme stood under the motto: “Advancing understanding and management in Neurogastroenterology and Motility”. The associated Postgraduate Course provided participants with an update in the management of clinical problems in Neurogastroenterology and Motility.
A special moment in the opening ceremony was the presentation of the Lifetime Achievement Award to Professor David Grundy (UK).
Another special moment was the presentation of the Best Abstract - Basic Science that was granted to Peter Neckel for the paper “The many faces of Wnt: a regulator of proliferation, differentiation, and cell death in the enteric nervous system.“. Prizes were also awarded for Best Abstract - Translational Science to Joost Algera for the paper “Prediction of response to a gluten-free diet in IBS”.
The prize for Best Abstract - Clinical Science was received by Karen Van den Houte for her work “Efficacy and timing of a blinded powder reintroduction in IBS patients on a low FODMAP diet”.
In addition, 5 ESNM Young Investigator Awards were also selected as well as Trainee Prize 2021 that went to Silvia Cerantola for her Abstract "Impact of ciprofloxacin exposure on small bowel excitatory and inhibitory neuromuscular pathways in young adult mice". Congratulations to all the awardees!
New UEG and ESNM consensus on functional dyspepsia
Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and prognosis.
The Little Brain Big Brain (LBBB) meeting has successfully cultivated numerous high achieving scientists in the field of Neurogastroenterology and Motility for over 3 decades. It has a long-standing tradition of being a unique gathering, which normally involves retreating into a remote location, where select and elite early career scientists from the international field can present their most novel discoveries to their peers. This meeting was designed to encourage young scientists to engage in lengthy discussions which is the catalyst for networking and collaborations.
Graphic Abstract: The added value of symptom analysis during a rapid drink challenge in high-resolution esophageal manometry
One-line-comment: A significant proportion of patients with esophageal symptoms have a normal HRM or an inconclusive diagnosis performing the standard protocol. Provocative tests like RDC mimic normal eating conditions. Evaluating both symptoms and pressive patterns in RDC increases the specificity of esophageal motor testing and helps to discriminate between patients with symptoms associated with esophageal dysmotility or EGJ obstruction from patients with functional dysphagia.
Graphic Abstract: Ranking microbiome variance in inflammatory bowel disease: a large longitudinal intercontinental study
The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional variability of the gut microbiota is unclear.
New International Questionnaire Study: looking for participants Last year Prof. Jan Tack and Prof. Kok Ann Gwee jointly initiated a multicenter study entitled AEGIS (Asian European GastroIntestinal Symptoms). In 2018, both research groups have published contradictory results regarding symptom clusters in patients with a Disorder of the Gut-Brain Axis (DGBI). Now, they started investigating where the differences in results come from. Is it the difference in lifestyle in Eastern and Western countries? Is it the difference in the questionnaire that was used in both studies (Rome IV and the Enhanced Asian Rome III questionnaire (EAR3Q))?
Genetic research in functional dyspepsia: The FunDysGWAS study: looking for participants A heritable component of functional dyspepsia (FD) has been demonstrated in cohorts of patients and community-based studies. However, genetic studies of FD have thus far been very scarce and mostly limited to candidate genes in small sample sets of cases and controls, hence no unequivocal FD risk locus has been proposed. Opposite to most human complex diseases, powered large-scale gene-hunting efforts and hypothesis-free genome-wide association studies (GWAS) have been completely lacking in FD, which represents some sort of “neglected disorder” in terms of genetic research.